American Brain Coalition
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Mission

The American Brain Coalition, a non-profit organization, seeks to advance the understanding of the functions of the brain, and to reduce the burden of brain disorders through public advocacy.

Vision

The ABC will be a strong and powerful voice for people with disabling brain disorders bringing together organizations that represent concerned and interested patients, families, and professionals. This voice will be used to advocate for increased support of research that will lead to better treatment; services and support that will improve patients’ quality of life; as well as a national commitment towards finding cures for individuals with disabling neurological and psychiatric disorders.

Goals

The ABC will leverage the resources of its membership to advocate for:

  • Research funding and progress towards a cure
  • Building a healthcare system more responsive to people with both acute and chronic brain disorders
  • Advancing public understanding about the cause, impact, and consequences of neurologic and psychiatric illness in our society through lobbying and advocacy efforts

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Sequential "in utero" labeling of earlier-born projection neurons electroporated at embryonic day 14.5 (E14.5) (green) and later-born neurons electroporated at E15.5 (red) in developing mouse neocortex. Dab1, a downstream effector of Reelin, was knocked down in the later-born neurons, and the image was obtained at postnatal day 7.

Reelin (cyan) is an essential regulator of the “inside-out” development of the neocortex. Knockdown of Dab1 caused terminal translocation failure of later-born neurons, thus disrupting the inside-out pattern. Magenta is nuclear staining.

Katsutoshi Sekine, Takao Honda, Takeshi Kawauchi, Ken-ichiro Kubo, and Kazunori Nakajima, 2011, 31: 9426-9439. Copyright © 2011, The Journal of Neuroscience. All rights reserved.

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